![]() ![]() Logistic regression models were created to determine the prognostic value of estimated Vd/Vt. Estimated Vd/Vt was calculated using the rearranged alveolar gas equation: Vd / Vt = 1 − where V ˙ CO 2 est is the estimated CO 2 production calculated from the Harris Benedict equation, minute ventilation (VE) is obtained from the ventilator rate and expired tidal volume and PaCO 2 from arterial gas analysis. Secondary analysis of the original data from two prospective studies of ALI patients. The objective of this study was to determine prognostic value of Vd/Vt estimated from routinely collected pulmonary variables. ![]() The measurement of Vd/Vt is based on the analysis of expired CO 2 which is not a part of standard practice thus limiting widespread clinical application of this method. ![]() Dead-space fraction (Vd/Vt) has been shown to be a powerful predictor of mortality in acute lung injury (ALI) patients. ![]()
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